Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis"
Dataset type: Lipidomic
Data released on August 25, 2017
Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes, such as cell proliferation, apoptosis, immunity, angiogenesis and inflammation.
In this study, an untargeted lipidomics approach was used to study the lipid profiles in psoriasis and identify lipid metabolite signatures for psoriasis through ultra-performance liquid chromatography-quadrupole tandem mass spectrometry. Plasma samples from 90 participants (45 healthy and 45 psoriasis patients) were collected and detected. Statistical analysis was applied to find different features between the two subjects. In addition, ELISA was performed to examine differential expression lipids in psoriatic patient plasma. We finally identified several differential expression lipids including LPAs, LysoPCs, PIs, PCs and PAs, among these metabolites, LPAs, LysoPCs and PAs were significantly increased, while PCs and PIs were down-regulated in psoriasis group.
Additional details
Read the peer-reviewed publication(s):
(PubMed: 29046044)
Additional information:
https://github.com/ZengVera/psoriasis
Accessions (data generated as part of this study):
MTBLS:
MTBLS408
Sample ID | Taxonomic ID | Common Name | Genbank Name | Scientific Name | Sample Attributes |
---|---|---|---|---|---|
MS15006001_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006002_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006003_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006004_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006005_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006007_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006008_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006009_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006010_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |
MS15006011_POS | 9606 | Human | human | Homo sapiens | Description:plasma sample Analyte type:lipids Experiment type:LC-MS/MS ... + |