Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis"

Dataset type: Lipidomic
Data released on August 25, 2017

Zeng C; Wen B; Hou G; Lei L; Mei Z; Jia X; Chen X; Zhu W; Li J; Kuang Y; Zeng W; Su J; Liu S; Peng C; Chen X (2017): Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis" GigaScience Database. http://dx.doi.org/10.5524/100341

DOI10.5524/100341

Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes, such as cell proliferation, apoptosis, immunity, angiogenesis and inflammation.
In this study, an untargeted lipidomics approach was used to study the lipid profiles in psoriasis and identify lipid metabolite signatures for psoriasis through ultra-performance liquid chromatography-quadrupole tandem mass spectrometry. Plasma samples from 90 participants (45 healthy and 45 psoriasis patients) were collected and detected. Statistical analysis was applied to find different features between the two subjects. In addition, ELISA was performed to examine differential expression lipids in psoriatic patient plasma. We finally identified several differential expression lipids including LPAs, LysoPCs, PIs, PCs and PAs, among these metabolites, LPAs, LysoPCs and PAs were significantly increased, while PCs and PIs were down-regulated in psoriasis group.

Additional details

Read the peer-reviewed publication(s):

Zeng, C., Wen, B., Hou, G., Lei, L., Mei, Z., Jia, X., … Chen, X. (2017). Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis. GigaScience, 6(10). doi:10.1093/gigascience/gix087

Additional information:

https://github.com/ZengVera/psoriasis

Accessions (data included in GigaDB):

MTBLS: MTBLS408





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
MS15006001_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
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MS15006002_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006003_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006004_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006005_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006007_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006008_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006009_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006010_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006011_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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Displaying 1-10 of 90 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
Tabular dataCSV8.25 MB2017-08-23
Tabular dataCSV14.62 MB2017-08-23
GitHub archivearchive76.98 MB2017-08-21
ReadmeTEXT1.93 KB2017-08-21
Displaying 1-4 of 4 File(s).
Funding body Awardee Award ID Comments
National Natural Science Foundation of China X Chen 81430075 key project
National Natural Science Foundation of China C Peng 81572679
Natural Science Foundation of Hunan province C Peng 2015JJ2161
Date Action
August 25, 2017 Dataset publish
October 17, 2017 Manuscript Link added : 10.1093/gigascience/gix087